Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide
A biocompatible photooxygenation catalyst that can selectively oxygenate and degrade
the pathogenic aggregation of Alzheimer’s disease (AD)-related amyloid-β peptide (Aβ)
under near-infrared light irradiation has been developed. The catalyst oxygenates
Aβ embedded under the skin of a living mouse and diminishes the intact Aβ level in
an AD-model mouse brain. The new catalyst is potentially applicable for the treatment
of peripheral amyloid diseases and AD.
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