Pathophysiology of Acute SCI – InVivo Therapeutics

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Acute spinal cord injury: a cascade of pathological events

Initial mechanical injury to the spinal cord begins a cascade of response that leads to further damage to the neural tissue, known as secondary injury. Unchecked, this response can lead to progressive cyst formation and glial scarring. Interrupting this cascade and attempting to reduce the loss of white matter is one strategy for limiting damage and restoring function.

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